Biguanide
What Is Biguanide?
Biguanide oral drugs have long been used as drugs for diabetes. They mainly improve insulin resistance and act to suppress rises in blood sugar. In recent years, they have an action that improves blood-sugar metabolism, and as a result they can be helpful for weight management. At our clinic, considering the patient’s constitution and medical history, we propose treatment with oral biguanide as needed.
How Biguanide Works
Biguanide drugs mainly have the following actions.
Suppresses the production of glucose in the liver
By reducing the amount of glucose produced from amino acids, lactic acid, and so on in the liver, it suppresses rises in blood sugar.
Improves insulin resistance in skeletal muscle
It improves the working of insulin, making glucose easier to use in the muscles.
The Difference from GLP-1 Treatment
Our clinic also provides GLP-1 treatment.
| Rybelsus® Mounjaro® |
GLP-1 preparation | Appetite-suppressing action, action to delay gastric emptying |
|---|---|---|
| Metformin | Biguanide class | Action to improve metabolism |
Because their mechanisms differ, combining them can, in some cases, be expected to provide more stable weight management.
Recommended For
- Those who find it hard to lose weight with dietary restriction alone
- Those who often consume sweets and carbohydrates
- Those concerned about a constitution prone to weight gain
- Those who want to improve their constitution as an adjunct to GLP-1 treatment
- Those with a BMI of 25 or more who want to manage their weight
About Side Effects
Gastrointestinal symptoms are mostly seen. In most cases, they are eased by starting with a small dose.
Common side effects
- Diarrhea
- Abdominal bloating
- Stomach discomfort
Other side effects
- Long-term use can cause vitamin B12 deficiency.
We provide vitamin B12 supplementation as needed.
Rare serious side effects
- Lactic acidosis (more likely with reduced kidney function, severe dehydration, etc.)
Those Who Cannot Use It
The following people cannot use metformin.
- Those with type 1 diabetes
- Those with a history of lactic acidosis
- Those with severe kidney impairment
- Those with severe liver impairment
- Those who may be in a hypoxic state, such as those with severe heart or respiratory disease
- Those who are dehydrated or prone to dehydration
- Those with a history of heavy alcohol consumption
- Those in a state of malnutrition
- Those who are pregnant or breastfeeding
In addition, the doctor may decide to refrain from use depending on your medical history and condition.
Frequently Asked Questions (FAQ)
Q Can I lose weight with biguanide alone?
A
The degree of weight loss varies by individual, but biguanide is a drug that supports weight management by improving blood-sugar metabolism. You can expect an effect by combining it with lifestyle improvements such as reviewing the content and amount of your diet and getting moderate exercise.
Q How long do I take it?
A
There is no set period. We decide whether to continue or stop in consultation, taking into account your target weight, health condition, and so on.
Q What should I do if side effects appear?
A
Gastrointestinal symptoms such as diarrhea and abdominal discomfort are eased by starting with a small dose. If symptoms persist, please consult the doctor.
Q Can it be combined with GLP-1 treatment?
A
Yes. GLP-1 preparations mainly have an appetite-suppressing action, while biguanide has an action that improves metabolism. Because their mechanisms differ, combining them can, depending on your constitution, stabilize weight management.